How Enteroviruses Change Our Cells
Functional characterization of the enteroviral degradome
This project aims to understand how common viruses called enteroviruses change the cells they infect, which could help us find new ways to fight illnesses like gastroenteritis and brain inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11111337 on NIH RePORTER |
What this research studies
Enteroviruses are common human viruses that can cause a range of health issues, from stomach flu to more serious conditions like brain inflammation and heart problems. We currently don't fully understand how these viruses take over and change our cells once they infect them. This research looks closely at specific proteins within our cells that enteroviruses target and break down. By understanding these interactions, we hope to discover new ways our bodies fight off these infections and identify potential targets for future treatments.
Who could benefit from this research
Good fit: Patients who have experienced or are at risk for enteroviral infections, including those affecting the gut, lungs, heart, or brain, could potentially benefit from future treatments developed from this research.
Not a fit: Patients without enteroviral infections or related conditions would not directly benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating or preventing diseases caused by enteroviruses, such as gastroenteritis, pneumonia, and encephalitis.
How similar studies have performed: This project builds upon recent findings that identified specific cellular proteins targeted by enteroviruses, with initial studies showing promising results in activating immune responses and inhibiting viral replication in lab settings.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Saeed, Mohsan — Boston University Medical Campus
- Study coordinator: Saeed, Mohsan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.