How ENPP1 affects bone mass in humans
ENPP1 regulation of mammalian bone mass
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11093408
This study is looking at how a specific enzyme called ENPP1 affects bone health in people with conditions like rickets and osteoporosis, hoping to find better treatments for those who have low bone mass and unusual calcifications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11093408 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ENPP1 enzyme in regulating bone mass and mineralization disorders. It focuses on patients with conditions like Autosomal Recessive Hypophosphatemic Rickets and osteoporosis, which are linked to ENPP1 deficiencies. By studying the signaling pathways influenced by ENPP1, the research aims to uncover mechanisms behind paradoxical mineralization, where patients have low bone mass alongside abnormal calcifications. The findings could lead to improved therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates include individuals with ENPP1 deficiencies, such as those with Autosomal Recessive Hypophosphatemic Rickets or osteoporosis.
Not a fit: Patients without ENPP1-related conditions or those not experiencing mineralization disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients suffering from bone mineralization disorders.
How similar studies have performed: Previous research has shown promising results in understanding bone mineralization disorders, but this specific approach to ENPP1 regulation is relatively novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRADDOCK, DEMETRIOS — YALE UNIVERSITY
- Study coordinator: BRADDOCK, DEMETRIOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.