How enjoyable activities can help improve stress resilience

Stress resilience by natural rewards: neurocircuit mechanisms

NIH-funded research University of Cincinnati · NIH-10669656

This study is looking at how doing fun activities, like hobbies and sports, can help people handle stress better and feel happier, using rats to learn about how the brain works when we don’t have enough of these enjoyable experiences.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Cincinnati NIH-funded
Lab location1 site (Cincinnati, United States)
Project IDNIH-10669656 on NIH RePORTER

What this research studies

This research investigates how engaging in pleasurable activities, like hobbies and sports, can enhance stress resilience and improve mood. It uses a rat model to explore the effects of limited access to natural rewards, such as sucrose, on stress-related behaviors. The study aims to understand the brain mechanisms involved, particularly how certain brain regions interact to buffer against the negative effects of chronic stress. By identifying these mechanisms, the research seeks to develop strategies that could help people manage stress more effectively.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals experiencing chronic stress or related mental health issues, such as anxiety or depression.

Not a fit: Patients who do not experience chronic stress or related mental health conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for improving mental health and resilience against stress-related disorders.

How similar studies have performed: Other research has shown promising results in using natural rewards to improve stress resilience, indicating that this approach has potential for success.

Where this research is happening

Cincinnati, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.