How energy metabolism affects bone health in aging
Official title: Energy Metabolism in Osteoblasts and Bone Health
Funded at University of Rochester · NIH-11079526 · Data updated 2026-11-12
This study looks at how the energy use of bone-building cells changes as we get older and how that affects our bone health, hoping to find new ways to help keep our bones strong as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $388,723 |
| NIH project number | 5R01AG080188-02 |
| Project ID | NIH-11079526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing bone health issues or those at risk of osteoporosis.
✕Less likely to help
Patients with acute bone injuries or those not experiencing age-related bone health decline may not benefit from this research.
What this research studies
This research investigates the role of energy metabolism in osteoblasts, the cells responsible for bone formation, and how it impacts bone health as we age. The study aims to clarify conflicting data on whether osteoblasts primarily use aerobic glycolysis or mitochondrial oxidative phosphorylation for energy. By examining the metabolism of various substrates like glucose, glutamine, and fatty acids in osteoblasts, the research seeks to understand how these processes change with age and contribute to bone health. The findings could provide insights into the mechanisms of bone aging and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related bone loss and improving overall bone health.
How similar studies have gone: Previous research has shown promising results in understanding energy metabolism in other tissues, suggesting potential for success in this area as well.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Eliseev, Roman — University of Rochester
- Study coordinator: Eliseev, Roman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.