How energy metabolism affects bone growth in developing chondrocytes
Official title: Mitochondrial Respiration and The Biology of Growth Plate Chondrocytes
Funded at University of Pennsylvania · NIH-11126399 · Data updated 2026-11-12
This study looks at how the way our cells use energy affects the growth of important bone cells in developing bones, and it hopes to help people understand bone growth issues better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 3, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $459,820 |
| NIH project number | 1R01AR084536-01A1 |
| Project ID | NIH-11126399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit are children with growth plate disorders or conditions affecting bone development.
✕Less likely to help
Patients with fully developed bones or those not experiencing growth-related issues may not receive any benefit from this research.
What this research studies
This research investigates the role of energy metabolism in the differentiation of chondrocytes, which are crucial for bone development. It focuses on how processes like glycolysis and oxidative phosphorylation influence the growth and health of these cells in the fetal growth plate. By studying mutant mice lacking a specific mitochondrial factor, the research aims to understand how energy production impacts bone growth and development. Patients may benefit from insights into conditions related to bone growth and development.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bone growth disorders in children.
How similar studies have gone: Other research has shown promising results in understanding the metabolic regulation of cell differentiation, suggesting potential for success in this area.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Schipani, Ernestina — University of Pennsylvania
- Study coordinator: Schipani, Ernestina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.