NIH-funded research R01 grant

How emotions and body signals predict return to substance use after leaving treatment

Official title: Interplay of Affect and Physiology in the Real-Time Prediction of Return to Use During Community Reintegration of Substance Users

Funded at University of Rhode Island · NIH-11310172 · Data updated 2026-11-12

This project tracks emotions and wearable body signals in people leaving residential substance treatment to spot moments when they might be likely to use again.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Rhode Island
NIH-funded
Lab location1 site (Kingston, United States)
Project startMay 1, 2024
Project endFebruary 28, 2029
Funding year2026
Award (this year)$679,078
NIH project number5R01DA058636-03
Project IDNIH-11310172 on NIH RePORTER

Who could benefit from this research

Could help

Adults (21+) who are leaving or have recently left residential substance use treatment and are willing to wear a sensor and answer brief mobile surveys.

Less likely to help

People under 21, those not coming from residential SUD treatment, or anyone unwilling to use wearables or mobile surveys may not benefit from joining this project.

What this research studies

You would wear a small biosensor and get brief phone prompts throughout the day to report how you feel while the study records physiological signals like heart rate and skin responses. The team focuses on the high-risk period soon after discharge—especially the first 30 days—to see which emotional ups and downs and body changes come right before return to use. Researchers combine the momentary self-reports and sensor data to build models that predict risk in real time. The aim is to learn when people need extra support during community reintegration so help can be offered at the right moments.

Why it matters

Potential benefit: If successful, this work could help deliver timely supports to prevent or delay return to substance use after treatment.

How similar studies have gone: Previous studies using mobile surveys and wearables have shown promise for spotting short-term risk signals, but real-time relapse prediction during community reintegration remains an emerging and still-developing approach.

Where this research is happening

  • University of Rhode Island
    Kingston, United States
    Active

Researchers

  • Principal investigator: Weiss, Nicole Holland — University of Rhode Island
  • Study coordinator: Weiss, Nicole Holland

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.