How emergency neutrophil production affects heart healing after a heart attack
Official title: The Role of Emergency Granulopoiesis in Wound Healing after Myocardial Infarction
Funded at University of Louisville · NIH-10903097 · Data updated 2026-11-12
This study is looking at how quickly your body makes certain white blood cells called neutrophils after a heart attack, to see if they help heal your heart and improve recovery, so you can feel better after your experience.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $35,822 |
| NIH project number | 1F31HL174069-01 |
| Project ID | NIH-10903097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
✕Less likely to help
Patients who have not had a myocardial infarction or those with chronic heart conditions unrelated to acute events may not benefit from this research.
What this research studies
This research investigates the role of emergency granulopoiesis, a process that rapidly produces neutrophils, in the healing of heart tissue after a myocardial infarction (heart attack). It focuses on understanding how these neutrophils function and whether their production affects scar formation and heart recovery. By examining the balance between beneficial and harmful neutrophil responses, the study aims to uncover new insights into heart failure post-MI. Patients may be monitored for neutrophil levels and their impact on recovery outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart attack patients by optimizing neutrophil responses to enhance healing.
How similar studies have gone: While the specific focus on emergency granulopoiesis in heart healing is novel, related research has shown that neutrophil dynamics play a critical role in recovery from myocardial infarction.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Stephan, Jonah — University of Louisville
- Study coordinator: Stephan, Jonah
Related research
Other NIH-funded projects on the same topics.
-
Immunomodulatory therapy to speed up healing after oral cavity injuries in kids
A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.
-
Aiming to slow dangerous lung inflammation to help fight bacterial infections like tuberculosis
A patient-facing program tests whether stopping a specific inflammatory cell (Spp1+ macrophages) from overreacting can help control tuberculosis and possibly improve outcomes in other inflammatory diseases.
-
Engineered protein materials to study wound healing and blood vessels
A researcher team at the University of New England is studying how the environment around a protein changes its behavior to better understand wound healing and blood vessel formation.
-
Understanding how healing tissue uses tiny messengers and scaffolds to repair wounds
A study to learn how cells talk to each other and how tiny vesicles and the extracellular matrix help skin wounds heal better.
-
Hormone signals and sex differences in how wounds heal
This grant explores how male- and female-specific hormones affect wound healing and scarring, with the goal of improving treatments for people who heal poorly.
-
Therapeutic extracellular vesicles to boost skin wound healing
A research grant is exploring how tiny cell messengers called extracellular vesicles can be engineered to improve skin wound repair in injury models.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.