How emergency neutrophil production affects heart healing after a heart attack
The Role of Emergency Granulopoiesis in Wound Healing after Myocardial Infarction
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF LOUISVILLE · NIH-10903097
This study is looking at how quickly your body makes certain white blood cells called neutrophils after a heart attack, to see if they help heal your heart and improve recovery, so you can feel better after your experience.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10903097 on ClinicalTrials.gov |
What this research studies
This research investigates the role of emergency granulopoiesis, a process that rapidly produces neutrophils, in the healing of heart tissue after a myocardial infarction (heart attack). It focuses on understanding how these neutrophils function and whether their production affects scar formation and heart recovery. By examining the balance between beneficial and harmful neutrophil responses, the study aims to uncover new insights into heart failure post-MI. Patients may be monitored for neutrophil levels and their impact on recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
Not a fit: Patients who have not had a myocardial infarction or those with chronic heart conditions unrelated to acute events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart attack patients by optimizing neutrophil responses to enhance healing.
How similar studies have performed: While the specific focus on emergency granulopoiesis in heart healing is novel, related research has shown that neutrophil dynamics play a critical role in recovery from myocardial infarction.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEPHAN, JONAH — UNIVERSITY OF LOUISVILLE
- Study coordinator: STEPHAN, JONAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.