How eczema (atopic dermatitis) progresses in children
Atopic dermatitis: mechanisms of disease progression
This project follows children with eczema to find patterns in their skin, gut, airways, and blood that predict who may develop allergies or asthma.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11307661 on NIH RePORTER |
What this research studies
If my child joins, clinicians will follow them over time with regular clinic visits and sample collection. They will collect skin, stool, airway and blood samples and use many lab tests and measurements to group children by shared symptoms and biology. The team uses these groups to look for early signs that predict whether a child will go on to develop food allergies, allergic rhinitis, or asthma. The study is focused on young children and emphasizes detailed, repeated measurements rather than testing a treatment.
Who could benefit from this research
Good fit: Young children (infants through pre-teens) diagnosed with atopic dermatitis/eczema, especially those with early-onset disease, are the ideal participants.
Not a fit: Adults, people without eczema, or participants seeking immediate changes to their treatment are unlikely to receive direct therapeutic benefit from this observational cohort.
Why it matters
Potential benefit: If successful, this work could help doctors predict which children with eczema are most likely to develop other allergic conditions and guide earlier prevention or personalized care.
How similar studies have performed: This builds on prior atopic march and cohort research but is relatively novel as the first U.S. early-life mechanistic cohort using multiple biological measures to define subgroups and predict outcomes.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Khurana Hershey, Gurjit K. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Khurana Hershey, Gurjit K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.