How eating affects inflammation in diabetes and bowel disease
Official title: Postprandial activation of hyaluronan-MARCO axis contributes to systemic chronic inflammation
Funded at Baylor College of Medicine · NIH-11083686 · Data updated 2026-11-12
This study is looking at how what you eat affects inflammation in people with type 2 diabetes and inflammatory bowel disease, focusing on a substance that increases after meals and may cause inflammation, to find better ways to manage these conditions, including possible treatments like weight-loss surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $433,816 |
| NIH project number | 5R01DK136532-03 |
| Project ID | NIH-11083686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with type 2 diabetes or inflammatory bowel disease who experience chronic inflammation.
✕Less likely to help
Patients without type 2 diabetes or inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the relationship between eating and inflammation in patients with type 2 diabetes and inflammatory bowel disease. It focuses on how a substance called hyaluronan increases after meals and its role in triggering inflammation. By studying animal models, the researchers aim to understand how this process works and how it can be influenced by treatments like bariatric surgery. The goal is to uncover new insights that could lead to better management of chronic inflammation in these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic inflammation in patients with type 2 diabetes and inflammatory bowel disease.
How similar studies have gone: Previous research has shown that understanding postprandial inflammation can lead to significant insights in related conditions, suggesting potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Zhu, Yi — Baylor College of Medicine
- Study coordinator: Zhu, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.