How eating affects heart and metabolic health markers
Official title: Mixed meal tolerance test elicited metabolite responses as novel markers of cardiometabolic risk
Funded at Beth Israel Deaconess Medical Center · NIH-11036256 · Data updated 2026-11-12
This study is looking at how your body reacts to a mixed meal to help us understand your heart and metabolic health better, and it's for people who want to learn more about how their diet might affect their risk for conditions like insulin resistance and obesity.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $190,670 |
| NIH project number | 5K23HL171855-02 |
| Project ID | NIH-11036256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with varying levels of cardiometabolic risk, including those with diabetes, obesity, or metabolic syndrome.
✕Less likely to help
Patients who are not at risk for cardiometabolic disorders or those who do not consume mixed meals may not benefit from this research.
What this research studies
This research investigates how the body's response to a mixed meal can reveal important information about heart and metabolic health. Participants will undergo a mixed meal tolerance test (MMTT) to measure changes in various metabolites in their blood. By analyzing these changes, researchers aim to identify new markers that indicate cardiometabolic risk factors such as insulin resistance and obesity. The study will involve over 2,400 individuals from the Framingham Heart Study, providing a comprehensive look at how diet impacts metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to better ways to assess and manage cardiometabolic risks in patients.
How similar studies have gone: Previous research has shown promising results in identifying metabolic markers related to cardiometabolic health, suggesting this approach may yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Mi, Michael — Beth Israel Deaconess Medical Center
- Study coordinator: Mi, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.