How early placental cells develop in healthy and preeclamptic pregnancies
Modeling Normal and Abnormal Trophoblasts
['FUNDING_R01'] · UNIVERSITY OF MISSOURI-COLUMBIA · NIH-11314593
Researchers compare early placental cells from pregnancies with and without preeclampsia to learn what goes wrong.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI-COLUMBIA (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-11314593 on ClinicalTrials.gov |
What this research studies
You might be asked to provide tissue or cells from a pregnancy that researchers turn into induced pluripotent stem cells and then guide into the two main early placental cell types. They will grow these cells in 3-D organoids and use chemical signals like BMP4 to push them toward syncytiotrophoblast or extravillous trophoblast fates. By comparing cells from early-onset preeclampsia and healthy pregnancies, they will look for defects in how these cells form and function. This lab-based work aims to point toward new tests or treatments rather than provide immediate clinical care.
Who could benefit from this research
Good fit: Ideal candidates would be people who had pregnancies complicated by early-onset preeclampsia and healthy pregnant donors willing to provide tissue or cells for research.
Not a fit: People seeking immediate treatment for preeclampsia will not receive direct clinical benefit from this laboratory-focused project.
Why it matters
Potential benefit: Could reveal early placental problems that lead to better tests or new ways to prevent or treat preeclampsia.
How similar studies have performed: iPSC and organoid models have provided new insights into placental biology, but applying these methods specifically to early-onset preeclampsia is a relatively new approach.
Where this research is happening
COLUMBIA, UNITED STATES
- UNIVERSITY OF MISSOURI-COLUMBIA — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHULZ, LAURA CLAMON — UNIVERSITY OF MISSOURI-COLUMBIA
- Study coordinator: SCHULZ, LAURA CLAMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.