How early metal exposure affects children's immune response to vaccines
Early-life metal exposures, mitochondrial heteroplasmy, and child antibody response to vaccination
This study is looking at how being around metals like arsenic and lead when kids are young might change how well their bodies respond to vaccines, and it's for families with children from birth to age 15.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10880618 on NIH RePORTER |
What this research studies
This research investigates how exposure to metals like arsenic and lead during early life influences children's immune responses to vaccinations. By studying children from birth to age 15, the researchers will measure levels of antibodies produced in response to common vaccines at various ages. The study will analyze samples from different sources, including blood and urine, to understand the impact of these environmental exposures on immune function. This research aims to fill a critical gap in knowledge regarding how early-life exposures can affect long-term health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0 to 15 years who have been exposed to environmental metals.
Not a fit: Patients who are older than 15 years or have not been exposed to the metals being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and public health policies that protect children from harmful environmental exposures.
How similar studies have performed: Previous research has indicated that early-life environmental exposures can significantly impact immune function, suggesting that this study builds on established findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Colicino, Elena — Icahn School of Medicine at Mount Sinai
- Study coordinator: Colicino, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.