How early lung development affects chronic lung disease in adulthood
Official title: Developmental Origins of COPD
Funded at Stanford University · NIH-11291185 · Data updated 2026-11-12
This study looks at how lung problems in preterm babies might affect their breathing as they grow up, especially in relation to developing COPD later in life, and it aims to find ways to help these babies breathe better in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $526,842 |
| NIH project number | 7R01HL157373-05 |
| Project ID | NIH-11291185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants who are at risk for bronchopulmonary dysplasia and subsequent lung function decline.
✕Less likely to help
Patients who are not preterm or do not have a history of lung development issues may not benefit from this research.
What this research studies
This research investigates how lung function established in infancy can influence the risk of developing Chronic Obstructive Pulmonary Disease (COPD) later in life. It focuses on preterm infants who may experience lung inflammation leading to bronchopulmonary dysplasia, which can alter lung development. By using a specialized mouse model, the study examines the effects of early lung inflammation on lung structure and function, aiming to uncover the mechanisms that link early lung issues to long-term respiratory problems. The findings could help identify early interventions for at-risk infants.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing COPD in individuals who experienced lung issues as infants.
How similar studies have gone: Other research has shown that early lung development significantly impacts long-term respiratory health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Benjamin, John — Stanford University
- Study coordinator: Benjamin, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.