How early life stress affects inflammation and kidney health in lupus patients
Early Life Stress Promotes an Inflammatory Phenotype Leading to Vascular Impairment and Lupus Nephritis Severity
This study is looking at how stress in early life might make lupus worse and increase heart problems, using mice to learn more about how this happens, which could help find better treatments for people with lupus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10897068 on NIH RePORTER |
What this research studies
This research investigates the impact of early life stress on the severity of systemic lupus erythematosus (SLE) and its association with cardiovascular disease. By using a mouse model, the study examines how early stress exposure leads to inflammation and vascular dysfunction, which may worsen kidney health in lupus patients. The researchers aim to understand the mechanisms behind these effects, focusing on the role of immune cells and mitochondrial dysfunction. This knowledge could help identify new treatment strategies for those affected by SLE.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of early life stress and a diagnosis of systemic lupus erythematosus.
Not a fit: Patients without a history of early life stress or those not diagnosed with lupus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of lupus and its complications, potentially enhancing patient outcomes.
How similar studies have performed: Previous research has shown that early life stress can lead to increased inflammation and health risks, suggesting that this approach may yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Kellum, Cailin — University of Alabama at Birmingham
- Study coordinator: Kellum, Cailin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.