How early life injuries affect pain sensitivity in the spinal cord
Neuromodulatory regulation of synaptic plasticity in spinal nociceptive circuits
This study is looking at how injuries we experience early in life might change the way our bodies handle pain later on, especially by focusing on a brain chemical called dopamine that helps send pain signals, which could help us understand why some people have more pain than others as they grow up.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11070314 on NIH RePORTER |
What this research studies
This research investigates how early life injuries can change the way pain signals are processed in the spinal cord, potentially leading to increased pain sensitivity later in life. The study focuses on understanding the role of neuromodulatory signals, particularly those involving dopamine, in strengthening the connections between nerve cells that transmit pain signals. By examining these mechanisms, the research aims to uncover how early injuries can 'prime' the nervous system for heightened pain responses. This could lead to new insights into chronic pain conditions and their origins.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced early life injuries and are currently suffering from chronic pain.
Not a fit: Patients who have not experienced early life injuries or do not suffer from chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain by targeting the underlying mechanisms that increase pain sensitivity.
How similar studies have performed: Other research has shown promising results in understanding pain mechanisms related to early life injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Baccei, Mark L — University of Cincinnati
- Study coordinator: Baccei, Mark L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.