How early life factors affect liver disease risk through gene regulation
Official title: Genomic Imprinting in the Development of NAFLD
Funded at Duke University · NIH-11072007 · Data updated 2026-11-12
This study is looking at how our genes and early life experiences might affect our chances of developing non-alcoholic fatty liver disease (NAFLD), and it aims to find easy ways to spot the disease early so we can take action to protect our liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 15, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $584,695 |
| NIH project number | 5R01DK137764-02 |
| Project ID | NIH-11072007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents at risk for NAFLD due to genetic or environmental factors.
✕Less likely to help
Patients with established liver disease or those without risk factors for NAFLD may not benefit from this research.
What this research studies
This research investigates how genetic factors influenced by early life experiences can lead to non-alcoholic fatty liver disease (NAFLD), a condition that can severely impact health. The study focuses on understanding specific regions of the genome that control gene expression and how their modification can increase the risk of developing NAFLD. By analyzing DNA methylation patterns and their effects on liver health, researchers aim to identify non-invasive markers for early detection and intervention. This approach combines genetic analysis with longitudinal data to provide insights into the development of liver disease from childhood through adulthood.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for NAFLD, particularly in children and adolescents.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Moylan, Cynthia a — Duke University
- Study coordinator: Moylan, Cynthia a
Related research
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Small blood particle signals and fatty liver in children and teens
Researchers are looking at whether molecules carried in tiny blood particles can explain or signal fatty liver disease in children and adolescents with excess weight.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.