How early life factors affect heart and metabolic health in South African children exposed to HIV.
Early life determinants of cardiometabolic health from birth to adolescence amongst HIV-exposed and unexposed South African children
This study looks at how being exposed to HIV and early infections affects the heart and metabolism in children, helping us understand their health from birth to their teenage years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10887513 on NIH RePORTER |
What this research studies
This research investigates the impact of early life factors on cardiometabolic health in children exposed to HIV compared to those who are not. It focuses on understanding how HIV exposure and early infections influence inflammation and metabolic changes from birth to adolescence. By analyzing a cohort of children, the study aims to identify specific metabolic profiles and their relationship with health outcomes. The research utilizes advanced metabolomics techniques to track changes in metabolic markers over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0 to 20 years who are either HIV-exposed but uninfected or HIV-unexposed.
Not a fit: Patients who are older than 20 years or those who are living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health strategies for children exposed to HIV, potentially reducing their risk of cardiometabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding metabolic dysfunction in children, making this approach both relevant and potentially impactful.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Pellowski, Jennifer Ann — Brown University
- Study coordinator: Pellowski, Jennifer Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.