How early life exposure to cadmium affects liver disease later in life
The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure
This study is looking at how being exposed to cadmium early in life might lead to liver problems later on, and it’s for anyone interested in understanding how environmental toxins can affect our health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10818582 on NIH RePORTER |
What this research studies
This research investigates the impact of cadmium exposure during early life on the development of non-alcoholic fatty liver disease (NAFLD) in adulthood. The study aims to understand the molecular mechanisms linking cadmium exposure to liver disease by analyzing DNA from newborns and using mouse and cell culture models. By identifying specific molecular signatures associated with cadmium, the researchers hope to develop strategies for preventing or reversing NAFLD. This research could provide valuable insights into how environmental toxins affect long-term health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who were exposed to cadmium during early life and are now experiencing symptoms related to liver disease.
Not a fit: Patients who have not been exposed to cadmium or do not have any liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention and treatment strategies for non-alcoholic fatty liver disease.
How similar studies have performed: Other research has shown that early life exposure to environmental toxins can lead to significant health issues later in life, suggesting that this approach may yield valuable insights.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Cowley, Michael — North Carolina State University Raleigh
- Study coordinator: Cowley, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.