How early life experiences affect gene expression and fertility across generations
Characterization of endocrine signaling and RNAi pathways as mechanisms regulating environmental programming in C. elegans
This study looks at how things like stress or lack of food during pregnancy or early childhood can affect genes and fertility later in life, using tiny worms to help us understand how these changes might be passed down to future generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10624328 on NIH RePORTER |
What this research studies
This research investigates how environmental factors experienced during fetal development or early childhood can lead to lasting changes in gene expression and fertility in adults. Using the model organism C. elegans, the study explores the molecular pathways involved in transgenerational inheritance of these effects. By examining how stressors like starvation impact endocrine signaling and RNA interference pathways, the research aims to uncover the biological mechanisms that link early life experiences to adult health outcomes. The findings could provide insights into how these effects are passed down through generations.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in the effects of early life experiences on health and fertility.
Not a fit: Patients who have not experienced significant early life environmental stressors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how early life experiences influence adult health, potentially informing prevention strategies for related diseases.
How similar studies have performed: While the specific approach using C. elegans is novel, there is existing research indicating that early life experiences can have lasting effects on health, suggesting potential for success.
Where this research is happening
Syracuse, United States
- Syracuse University — Syracuse, United States (Active)
Researchers
- Principal investigator: Hall, Sarah E — Syracuse University
- Study coordinator: Hall, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.