How early-life environmental exposures affect aging in children and adolescents
Early-life environmental exposure mixtures and biological age acceleration in children and adolescents: susceptibility, potential interactions and underlying mechanisms
This study is looking at how being around certain chemicals during pregnancy and early childhood might affect how kids age biologically, and it’s for families who want to understand how things like diet and weight can play a role in their children's health as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11047757 on NIH RePORTER |
What this research studies
This research investigates how exposure to environmental factors, particularly endocrine-disrupting chemicals (EDCs), during pregnancy and early life can influence biological aging in children and adolescents. It aims to understand the interactions between these exposures and other factors like diet and obesity that may affect telomere length, a marker of biological aging. By following participants over time, the study will explore how these factors contribute to health outcomes as children grow. The research employs advanced multi-omics techniques to analyze biological data and identify potential mechanisms behind these effects.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adolescents who have been exposed to environmental pollutants or have dietary and obesity-related concerns.
Not a fit: Patients who are not children or adolescents, or those without any exposure to the environmental factors being studied, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of how environmental factors influence aging and chronic disease risk in children, potentially guiding public health interventions.
How similar studies have performed: While the specific combination of factors being studied is novel, previous research has shown that environmental exposures can significantly impact health outcomes, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Valvi, Damaskini — Icahn School of Medicine at Mount Sinai
- Study coordinator: Valvi, Damaskini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.