How early life environment affects brain development after lead exposure
Early Life Environment Modifies Behavioral, Epigenetic, and Transcriptional Outcomes from Developmental Lead Exposure
This study is looking at how things like the care you receive and your surroundings when you're young can affect your brain and behavior, especially if you've been exposed to lead, to help find ways to support those who might be struggling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10850872 on NIH RePORTER |
What this research studies
This research investigates how different environmental and behavioral factors during early life can influence brain development and behavior, particularly after exposure to lead. It focuses on the impact of the quality of caregiving and the richness of the postnatal environment on cognitive and behavioral outcomes. The study examines how these factors interact with lead exposure to affect brain function, specifically looking at changes in DNA and gene expression in key brain areas. By understanding these relationships, the research aims to identify potential interventions for those affected by lead exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who have experienced lead exposure and come from varying socioeconomic backgrounds.
Not a fit: Patients who have not been exposed to lead or are over 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for mitigating the negative effects of lead exposure on brain development and behavior.
How similar studies have performed: Previous studies have shown promising results in understanding the effects of environmental factors on brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Schneider, Jay S — Thomas Jefferson University
- Study coordinator: Schneider, Jay S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.