How early life challenges affect brain development
Determining the impact of early adversity on the developing vertebrate brain
This study looks at how tough experiences in childhood can affect brain development, using zebrafish to help us understand the changes that happen and how they might lead to mental health challenges later on.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project ID | NIH-10580285 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of childhood trauma on brain development using zebrafish as a model. By examining hormonal, neuronal, and genetic changes caused by early life adversity, the study aims to uncover how these factors contribute to mental health issues later in life. Advanced techniques such as whole-brain imaging and CRISPR/Cas9 genetic screening will be employed to analyze brain function and structure at various developmental stages. The findings could provide valuable insights into the biological mechanisms linking childhood stress to adult psychiatric disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant childhood adversity and are currently facing mental health challenges.
Not a fit: Patients who have not experienced early life adversity or those with unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals affected by childhood trauma and related mental health disorders.
How similar studies have performed: Previous research has shown promising results in understanding the effects of early adversity on brain development using animal models, suggesting that this approach could yield valuable insights.
Where this research is happening
Boca Raton, United States
- Florida Atlantic University — Boca Raton, United States (Active)
Researchers
- Principal investigator: Duboue, Erik Rolando — Florida Atlantic University
- Study coordinator: Duboue, Erik Rolando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.