How early immune development affects vaccine response and respiratory diseases
Immune development in early life (IDEAL) shapes vaccine response, respiratory infectious diseaseand asthma
This study is looking at how a child's immune system develops in the early years and how that affects their response to vaccines and their chances of getting respiratory infections or asthma, with the goal of finding ways to help kids stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11051816 on NIH RePORTER |
What this research studies
This research investigates how immune development in early life influences responses to vaccines and the risk of respiratory infections and asthma. By studying well-defined childhood cohorts over time, the researchers aim to identify specific immune profiles that correlate with health outcomes. They will use advanced data analysis techniques and in vitro models to explore how to steer immune development away from disease-prone patterns. The study focuses on understanding the variability in immune responses among children to improve health interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and young children, particularly those at risk for respiratory infections or asthma.
Not a fit: Patients who are adults or those with established chronic respiratory conditions may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for respiratory diseases and asthma in children.
How similar studies have performed: Previous research has shown promise in understanding immune responses in adults, but this approach focusing on early life immune development is relatively novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Levy, Ofer — Boston Children's Hospital
- Study coordinator: Levy, Ofer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.