How early GABA signaling affects brain cell development and structure
Early GABAergic signaling influences axon morphology and cortical cell polarity
This study looks at how early brain signals help shape brain cells and their connections, and it aims to understand how problems with these signals might lead to issues in children's brain development, which could help find better treatments for kids with neurological disorders.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project ID | NIH-10875014 on NIH RePORTER |
What this research studies
This research investigates the role of early GABAergic signaling in the development of brain cells and their connections. It focuses on how disruptions in this signaling can lead to improper brain circuitry, which is linked to various childhood neurological disorders. By studying specific models that mimic human conditions, the research aims to understand how early signaling influences the morphology and organization of cortical cells. This could provide insights into potential therapeutic targets for improving treatment outcomes in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neurodevelopmental disorders, particularly those exhibiting symptoms of intellectual disability or epilepsy.
Not a fit: Patients with neurological disorders not related to GABA signaling or those with conditions outside the scope of childhood neurodevelopmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for childhood neurological disorders linked to GABA signaling.
How similar studies have performed: Previous research has shown promising results in understanding the role of GABA signaling in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Las Vegas, United States
- University of Nevada Las Vegas — Las Vegas, United States (Active)
Researchers
- Principal investigator: Hines, Rochelle Marie — University of Nevada Las Vegas
- Study coordinator: Hines, Rochelle Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.