How early exposure to microbes affects immune system development
Impact of early microbial exposure on immune ontogeny
This study is looking at how the germs we are exposed to early in life, like those from being born naturally versus by cesarean section or from taking antibiotics, can affect our immune system and our chances of getting sick later on, using mice to help us understand these effects better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10747605 on NIH RePORTER |
What this research studies
This research investigates how early life exposure to different microbial environments influences the development of the immune system and the risk of diseases later in life. By using a unique mouse model, the study aims to understand how factors like cesarean section births and antibiotic use impact immune cell generation from stem cells. The researchers will analyze the differences in immune responses between mice raised in clean versus 'dirty' environments, focusing on the transition from fetal to adult immune cell production. This could provide valuable insights into the mechanisms behind immune-related diseases in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults with a history of immune-related conditions, such as asthma or diabetes, particularly those with early life exposures of interest.
Not a fit: Patients who have not experienced significant early life microbial exposures or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing immune-related diseases in children and adults.
How similar studies have performed: Previous studies have shown promising results regarding the impact of early microbial exposure on immune health, suggesting that this approach could yield significant insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Rudd, Brian David — Cornell University
- Study coordinator: Rudd, Brian David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.