How early exposure to microbes affects immune system development
Impact of early microbial exposure on immune ontogeny
This study looks at how the germs that a mother is exposed to can affect her baby's immune system development, using mice to see how different living conditions influence important immune cells that help fight infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10703411 on NIH RePORTER |
What this research studies
This research investigates the impact of maternal microbial exposure on the development of the immune system in offspring. Using a unique mouse model, the study compares immune responses in mice born to mothers raised in clean versus dirty environments. The researchers aim to understand how these different exposures influence the development and function of CD8+ T cells, which are crucial for fighting infections. By exploring these mechanisms, the research seeks to uncover how early microbial environments shape long-term immune health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with immune-related conditions or those interested in understanding the role of early microbial exposure on health.
Not a fit: Patients who are not affected by immune system disorders or who have no interest in the effects of microbial exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses and preventing diseases in humans.
How similar studies have performed: Other research has indicated that early microbial exposure can significantly influence immune system development, suggesting that this approach may yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Rudd, Brian David — Cornell University
- Study coordinator: Rudd, Brian David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.