How early exposure to alcohol affects genes and behavior
Official title: Influence of early developmental ethanol exposure on genes, the mTOR signaling pathway and behavior
Funded at University of South Dakota · NIH-10686974 · Data updated 2026-11-12
This study is looking at how drinking alcohol during pregnancy affects brain development and behavior, using zebrafish to learn more about the possible genetic factors involved, which could help us find ways to support people with Fetal Alcohol Spectrum Disorder (FASD).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Dakota NIH-funded |
| Lab location | 1 site (Vermillion, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $249,000 |
| NIH project number | 5R00AA027567-05 |
| Project ID | NIH-10686974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have been diagnosed with Fetal Alcohol Spectrum Disorder or exhibit related behavioral issues.
✕Less likely to help
Patients who have not been exposed to alcohol during prenatal development are unlikely to benefit from this research.
What this research studies
This research investigates the impact of prenatal alcohol exposure on genetic factors and the mTOR signaling pathway, which is crucial for brain development and behavior. By using zebrafish as a model, the study aims to understand how early exposure to ethanol can lead to social behavior deficits and disruptions in dopamine functioning. The researchers will explore the genetic predispositions that may influence these outcomes, providing insights into the mechanisms behind Fetal Alcohol Spectrum Disorder (FASD). This work could help identify potential therapeutic targets for improving social behavior in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals affected by Fetal Alcohol Spectrum Disorder.
How similar studies have gone: Previous research has shown promising results in understanding the effects of prenatal alcohol exposure on behavior, but this specific approach using zebrafish is relatively novel.
Where this research is happening
-
University of South Dakota
Vermillion, United States Active
Researchers
- Principal investigator: Fernandes, Yohaan M — University of South Dakota
- Study coordinator: Fernandes, Yohaan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.