How early developmental factors control gene expression in animals
Official title: Developmental regulation of histone genes by pioneer factors and three-dimensional architecture
Funded at Emory University · NIH-11026396 · Data updated 2026-11-12
This study looks at how things from a mother affect the early development of baby animals, especially how they help control genes and cell growth, using fruit flies to learn more about these important processes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 15, 2023 |
| Project end | March 14, 2026 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31HD108974-03 |
| Project ID | NIH-11026396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the genetic and developmental aspects of early embryogenesis, particularly those with a family history of developmental disorders.
✕Less likely to help
Patients with established developmental conditions that are not related to early embryonic gene regulation may not benefit from this research.
What this research studies
This research investigates the role of maternal factors in the early stages of animal development, particularly focusing on how these factors influence gene expression and cellular differentiation. It examines the process of zygotic genome activation (ZGA), where the responsibility for transcription shifts from maternal factors to the zygote. The study aims to understand how specific regulatory proteins, known as pioneer factors, interact with histone genes to facilitate proper gene expression during early embryogenesis. By using model organisms like Drosophila, the research explores the mechanisms that ensure accurate timing of cell divisions and differentiation.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental disorders and improving reproductive health.
How similar studies have gone: Previous research has shown success in understanding gene regulation during early development, making this approach a promising continuation of established findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: O'haren, Thomas E — Emory University
- Study coordinator: O'haren, Thomas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.