How early dengue exposures shape immunity in Thai families
Official title: Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
Funded at Upstate Medical University · NIH-11120938 · Data updated 2026-11-12
Researchers are following multigenerational households in Thailand to learn how children’s earliest exposures to dengue and related viruses change their chances of getting sick later.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $427,769 |
| NIH project number | 5R01AI175941-03 |
| Project ID | NIH-11120938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children and family members living in dengue-endemic areas (especially in or near Kamphaeng Phet, Thailand) who can provide blood samples and be followed over time.
✕Less likely to help
People living outside dengue-endemic regions, those not enrolled in the household cohort, or those seeking immediate treatment for acute dengue are unlikely to directly benefit from this observational research.
What this research studies
This project follows a long-term family cohort in Kamphaeng Phet, Thailand, where team members regularly check for new dengue infections and collect blood samples. Children and other household members have antibody tests and clinical monitoring to record who gets sick and how severe illness becomes. The researchers compare immune markers from people with different early exposures to define laboratory signs that link to protection against multiple dengue types. Results will be used to create benchmarks that could help guide vaccine development and better interpret immune tests.
Why it matters
Potential benefit: If successful, the work could show which immune responses protect children from severe dengue and help guide safer, more effective vaccines and tests.
How similar studies have gone: Previous long-term dengue cohorts have shown durable multi-type immunity after repeat exposures, but precisely defining lab markers that predict protection across serotypes remains a newer aim.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Anderson, Kathryn B — Upstate Medical University
- Study coordinator: Anderson, Kathryn B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.