How early antibiotic use affects immune response to influenza in newborns
CD8+ tissue-resident immunity to primary and heterotypic Influenza A controlled by commensal microbiota
This study is looking at how giving antibiotics to newborns in the NICU might affect their immune system, especially the cells that help fight off viruses like the flu, to find better ways to keep babies healthy and reduce their chances of getting serious lung infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10913334 on NIH RePORTER |
What this research studies
This research investigates the impact of early-life antibiotic exposure on the immune system, specifically focusing on CD8+ T cells that are crucial for fighting viral infections like influenza. By studying neonates in the neonatal intensive care unit (NICU), the research aims to understand how antibiotics disrupt the development and function of these immune cells. The methodology includes advanced techniques such as flow cytometry and single-cell RNA sequencing to analyze changes in immune response. The goal is to identify ways to improve immunity in newborns and reduce the risk of severe viral pneumonia.
Who could benefit from this research
Good fit: Ideal candidates for this research are neonates who have received antibiotic treatment in the NICU.
Not a fit: Patients who are older than 21 years or those who have not been exposed to antibiotics in early life may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing antibiotic use in neonates, potentially reducing pneumonia-related mortality.
How similar studies have performed: Other research has indicated that early antibiotic exposure can negatively impact immune development, suggesting that this area of study is both relevant and necessary.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Stevens, Joseph Jacob — University of Cincinnati
- Study coordinator: Stevens, Joseph Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.