How dynein proteins work in our cells
Mechanisms of dynein regulation
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11138649
This research explores how important cell motors called dyneins are controlled, which could help us understand neurodegenerative diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11138649 on ClinicalTrials.gov |
What this research studies
Our cells rely on tiny motor proteins, like dynein, to move essential materials around, much like a delivery system. When these motors don't work correctly, it can lead to serious health problems, including brain and nerve disorders. This project aims to uncover the precise ways these dynein motors are regulated within our cells. By combining advanced techniques, we hope to learn how newly discovered proteins influence dynein's activity. This knowledge is crucial for understanding the root causes of many neurodevelopmental and neurodegenerative conditions.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the cellular processes that go awry in people with neurodevelopmental and neurodegenerative diseases.
Not a fit: Patients seeking immediate treatment options will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could reveal fundamental mechanisms behind neurodegenerative diseases, potentially leading to new targets for future treatments.
How similar studies have performed: While the general field of motor protein research is established, this project focuses on newly discovered dynein regulators, making this specific line of inquiry novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESANTIS, MORGAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: DESANTIS, MORGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Degenerative Neurologic Disorders, Disease