How Dying Cells Help Tissues Heal After Injury
Understanding Necrosis-Induced Tissue Regeneration
This work explores how signals from dying cells might help our bodies repair and regenerate tissues, especially after injuries like burns.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11140487 on NIH RePORTER |
What this research studies
When cells die, they release signals that can affect the cells around them, influencing how tissues recover from injury or disease. While we know this happens with one type of cell death called apoptosis, it's less clear if a different type, called necrosis, has a similar impact on healing. Necrosis is a rapid, uncontrolled cell death that occurs in many human conditions, including burns, and this project aims to understand what signals necrotic cells release and how they influence the surrounding tissue's ability to recover and regenerate. By uncovering these signals, we hope to find new ways to improve healing for patients.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals experiencing tissue damage from conditions like burn injuries, frostbite, or ischemic events.
Not a fit: Patients without conditions involving significant tissue necrosis or those seeking immediate clinical interventions would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's natural healing processes and improve recovery for patients with injuries like severe burns.
How similar studies have performed: While the signaling from apoptotic cells is well-characterized, the specific impact of necrotic cell signals on tissue regeneration is a novel area of investigation.
Where this research is happening
Scottsdale, United States
- Arizona State University-Tempe Campus — Scottsdale, United States (Active)
Researchers
- Principal investigator: Harris, Robin — Arizona State University-Tempe Campus
- Study coordinator: Harris, Robin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.