How drugs travel inside tumors
Mechanism of Intratumoral Transport of Particulate Drugs
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10531257
This study is looking at how tiny drug particles can get into tumors and spread effectively, which could help improve cancer treatments while reducing side effects for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10531257 on ClinicalTrials.gov |
What this research studies
This research investigates how particulate drugs, like those packaged in nanoparticles, penetrate and distribute within tumors. It focuses on understanding the biological barriers these drugs face, such as immune cells that may capture them before they reach the tumor. By using model drugs like doxorubicin, the study aims to uncover the mechanisms that allow these drugs to effectively enter and spread within tumor tissues. This could lead to improved drug delivery methods that enhance treatment efficacy while minimizing side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that are being treated with particulate drug therapies.
Not a fit: Patients who do not have tumors or are not receiving treatment with particulate drugs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by improving how drugs are delivered directly to tumors.
How similar studies have performed: Previous research has shown promise in using nanoparticles for drug delivery, indicating that this approach could be effective.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, SHU-HSIA — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: CHEN, SHU-HSIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.