How drug use affects memory and decision-making in the brain
Gene Regulation in Memory Circuits as a Consequence of Polysubstance Use
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10896244
This study looks at how using alcohol and methamphetamine together affects memory and decision-making by examining tiny fruit flies, which can help us find better ways to understand and treat addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10896244 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of polysubstance use, particularly alcohol and methamphetamine, on the brain's memory circuits. By studying the gene regulatory networks in fruit flies, the research aims to uncover how these substances alter brain function and influence decision-making. The approach combines genetic analysis with behavioral assessments to provide insights into the molecular mechanisms at play. Understanding these processes could lead to better strategies for addressing addiction and its consequences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of polysubstance use, particularly those who have used alcohol and methamphetamine.
Not a fit: Patients who have not engaged in polysubstance use or those with no history of addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for addiction by revealing how substance use impacts memory and decision-making.
How similar studies have performed: Other research has shown success in understanding the effects of substance use on brain function, but this specific approach using Drosophila is relatively novel.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAUN, KARLA R. — BROWN UNIVERSITY
- Study coordinator: KAUN, KARLA R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.