How DPEP1 influences the environment around adenomas to promote cancer progression
Shaping the Microenvironment by DPEP1 Facilitates Adenoma Progression
This study is looking at how a protein called DPEP1 might help adenomas, which are early growths that can lead to colorectal cancer, grow and develop by studying samples from people and special lab setups, with the hope of finding clues that could show which adenomas are more likely to turn into cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10926861 on NIH RePORTER |
What this research studies
This research investigates the role of dipeptidase-1 (DPEP1) in the progression of adenomas, which are precursors to colorectal cancer. By examining human specimens and using a unique co-culture system that combines adenoma organoids with neutrophils, the study aims to understand how DPEP1 facilitates communication between these cells. The researchers hypothesize that DPEP1 helps create a microenvironment that supports the growth of adenomas, potentially leading to cancer. This work could provide insights into the biological markers that indicate which adenomas are more likely to progress to colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diagnosed adenomas, particularly those with a family history of colorectal cancer or other risk factors.
Not a fit: Patients who have already been diagnosed with colorectal cancer or those without adenomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of adenomas at risk of progressing to colorectal cancer, allowing for earlier intervention and improved patient outcomes.
How similar studies have performed: Other research has shown promise in understanding the role of microenvironmental factors in cancer progression, making this approach both relevant and potentially impactful.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Coffey, Robert J. — Vanderbilt University Medical Center
- Study coordinator: Coffey, Robert J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.