How dopamine signaling during sleep affects memory
Official title: The functions of dopamine signaling during sleep in memory
Funded at University of Michigan at Ann Arbor · NIH-11021101 · Data updated 2026-11-12
This study looks at how certain brain cells that use dopamine help us remember important experiences while we sleep, and it could lead to new ways to improve memory for people who have memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $453,659 |
| NIH project number | 5R01NS131821-03 |
| Project ID | NIH-11021101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing memory issues or those interested in understanding the relationship between sleep and memory.
✕Less likely to help
Patients with no memory concerns or those not experiencing significant sleep disturbances may not benefit from this research.
What this research studies
This research investigates the role of dopamine neurons in the brain during sleep and how they contribute to the formation of long-term memories from significant experiences. By examining the activity of these neurons, the study aims to understand how memories are consolidated during sleep, particularly focusing on the integration of dopamine signaling with other brain regions involved in memory. Patients may benefit from insights into how sleep and dopamine influence memory, potentially leading to new treatments for memory-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatments for memory disorders by highlighting the importance of sleep and dopamine in memory consolidation.
How similar studies have gone: Previous research has shown promising results regarding the role of dopamine in memory processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Eban-Rothschild, Ada — University of Michigan at Ann Arbor
- Study coordinator: Eban-Rothschild, Ada
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.