How dopamine affects swimming behavior in zebrafish
Functional architecture of dopamine signaling within a zebrafish sensorimotor network
This study looks at how certain brain cells that make dopamine in baby zebrafish affect their swimming movements, helping us understand how these cells respond to what they see and how they control movement, which might also relate to how other animals move.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10877171 on NIH RePORTER |
What this research studies
This research investigates the role of dopamine-producing neurons in the hypothalamus of larval zebrafish and their influence on swimming behaviors. By using advanced techniques like functional imaging and optogenetics, the study examines how these neurons respond to sensory cues and control motor functions. The findings aim to uncover the complex interactions between dopamine signaling and locomotor activities, which could provide insights into similar mechanisms in other vertebrates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with movement disorders or those interested in the neurological basis of motor control.
Not a fit: Patients with conditions unrelated to dopamine signaling or motor control may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of dopamine's role in movement disorders, potentially leading to new treatments for conditions affecting motor control.
How similar studies have performed: Previous research has shown promising results in understanding dopamine's role in motor behaviors, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Douglass, Adam D — University of Utah
- Study coordinator: Douglass, Adam D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.