How donor diabetes affects corneal transplant success
The Impact of Donor Diabetes on Corneal Immune Cells and Graft Survival
['FUNDING_R01'] · SCHEPENS EYE RESEARCH INSTITUTE · NIH-10912654
This study looks at how diabetes in cornea donors might affect the success of corneal transplants, helping to find better ways to choose donor tissues for people needing eye surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCHEPENS EYE RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10912654 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of diabetes in corneal tissue donors on the survival of corneal transplants. It aims to understand how the diabetic status of donors influences the immune response in the cornea, which could affect the success of grafts. Using a mouse model, the study examines the behavior of immune cells in the cornea to determine if donor diabetes should be considered in tissue allocation decisions. The findings could lead to improved strategies for selecting donor tissues for transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring corneal transplants, particularly those who may benefit from improved donor tissue selection.
Not a fit: Patients who do not require corneal transplants or those whose conditions are unrelated to corneal grafting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the success rates of corneal transplants by refining donor selection criteria based on diabetes status.
How similar studies have performed: While the impact of recipient diabetes on graft survival is well-documented, the exploration of donor diabetes as a factor is novel and has not been extensively tested.
Where this research is happening
BOSTON, UNITED STATES
- SCHEPENS EYE RESEARCH INSTITUTE — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANA, REZA — SCHEPENS EYE RESEARCH INSTITUTE
- Study coordinator: DANA, REZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.