How donor age affects liver cell function and treatment effectiveness
The effect of donor age on the function and therapeutic efficacy of human hepatocyte-like cells
This study is looking at how the age of donors affects the performance of liver-like cells made from stem cells, with the goal of finding better and safer treatments for liver diseases, especially for those facing acute liver failure.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11035172 on NIH RePORTER |
What this research studies
This research investigates the impact of donor age on the function and therapeutic potential of human hepatocyte-like cells (h-iHLCs), which are derived from human induced pluripotent stem cells. The study aims to understand how age influences the metabolic capabilities of these cells, which are a promising alternative to traditional liver cell therapies. By exploring this relationship, the research seeks to enhance the effectiveness of cell-based treatments for liver diseases, particularly in cases of acute liver failure. Patients may benefit from a more effective and less invasive treatment option that utilizes their own cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from acute liver failure or other liver-related conditions who are over 21 years old.
Not a fit: Patients with chronic liver disease who do not meet the age or condition criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with liver diseases, reducing the need for liver transplants.
How similar studies have performed: While the use of human hepatocyte-like cells is a relatively novel approach, previous studies have shown promise in cell-based therapies for liver conditions.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Kirchner, Varvara a — Stanford University
- Study coordinator: Kirchner, Varvara a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.