How dolutegravir affects appetite and postpartum weight in mothers and babies
Appetite regulation with DTG based ART in postpartum women living with HIV and their infants (Ar-DART)
['FUNDING_R21'] · JOHNS HOPKINS UNIVERSITY · NIH-11162269
This project looks at how a common HIV medicine, dolutegravir, may change appetite and weight in postpartum women with HIV and their infants.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11162269 on ClinicalTrials.gov |
What this research studies
If you join, researchers will follow postpartum mothers living with HIV and their babies to see how dolutegravir-based ART relates to eating, activity, and body weight. They will build on an existing mother–infant cohort to collect measurements such as reported food intake, physical activity with accelerometers, and body composition in both mothers and infants. The study compares infants who were exposed to maternal DTG but are uninfected (HEU) with infants who were not exposed to HIV or DTG to look for differences in appetite and growth. Biological and behavioral data will be combined to look for mechanisms linking maternal DTG use to postpartum weight changes.
Who could benefit from this research
Good fit: Ideal candidates are postpartum women living with HIV who are taking or starting dolutegravir-based ART and their newborns or infants.
Not a fit: People who do not have HIV, are not on dolutegravir-based therapy, or are well beyond the postpartum period are unlikely to receive direct benefit from participating.
Why it matters
Potential benefit: Findings could help doctors choose or manage ART after childbirth to reduce excess postpartum weight and lower future risk of obesity and related diseases.
How similar studies have performed: Previous research has reported weight gain linked to dolutegravir, but using detailed appetite, activity, and infant growth measurements in postpartum mother–infant pairs is a newer, less-tested approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AIZIRE, JIM K — JOHNS HOPKINS UNIVERSITY
- Study coordinator: AIZIRE, JIM K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus