How DNA Topoisomerase II controls chromosome separation
Control of Chromosome Segregation by DNA Topoisomerase II
This study looks at how a protein called DNA Topoisomerase II helps cells divide correctly, which is important for preventing problems like cancer and birth defects, and it aims to find ways to use this knowledge to develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11061074 on NIH RePORTER |
What this research studies
This research investigates the role of DNA Topoisomerase II in ensuring accurate chromosome segregation during cell division. It focuses on a newly identified mechanism that delays the cell cycle when Topo II activity is insufficient, which is crucial for preventing errors that can lead to conditions like aneuploidy, birth defects, and cancer. By studying the molecular interactions involved in this process, the research aims to uncover how the activation of this control mechanism can be manipulated for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for aneuploidy-related conditions, including certain cancers and genetic disorders.
Not a fit: Patients with conditions unrelated to chromosome segregation errors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and birth defects caused by chromosome segregation errors.
How similar studies have performed: While the specific mechanism being studied is novel, similar approaches in understanding chromosome segregation have shown promise in other research.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Clarke, Duncan J. — University of Minnesota
- Study coordinator: Clarke, Duncan J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.