How DNA repair proteins work together to prevent cancer
The interplay of TIMELESS and PARP1 in DNA replication fork stability
This research explores how certain proteins help keep our DNA stable during cell division, which is important for preventing cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11118980 on NIH RePORTER |
What this research studies
Our DNA can be damaged when cells make copies, leading to problems like broken chromosomes that are linked to cancer. This project looks at how special proteins, like TIMELESS and PARP1, protect our DNA during this copying process. These proteins act like a shield, making sure DNA copying happens smoothly and preventing errors that could lead to tumor growth. By understanding how these protective mechanisms work, we hope to find new ways to fight diseases like cancer.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but it aims to benefit individuals affected by various cancers, especially those with DNA repair deficiencies like BRCA1/2.
Not a fit: Patients who do not have cancers related to DNA replication errors or who are not undergoing cancer treatment may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating cancers by targeting how DNA is repaired and protected.
How similar studies have performed: While the general concepts of DNA repair are known, the specific roles and interactions of TIMELESS and PARP1 in replication fork stability are still being explored, making this a novel area of focus.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Kim, Hyungjin — State University New York Stony Brook
- Study coordinator: Kim, Hyungjin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.