How DNA repair proteins work together to fix damage from UV light and pollution
Official title: DNA repair pathway coordination during damage processing
Funded at University of Pittsburgh at Pittsburgh · NIH-11005689 · Data updated 2026-11-12
This study looks at how certain proteins work together to fix DNA damage caused by things like UV light and pollution, which can lead to health problems like cancer and aging, and the findings could help develop new treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $80,224 |
| NIH project number | 5F32ES034982-02 |
| Project ID | NIH-11005689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of exposure to UV light or environmental pollutants, particularly those at risk for DNA damage-related conditions.
✕Less likely to help
Patients with no history of DNA damage or related conditions may not receive direct benefits from this research.
What this research studies
This research investigates how proteins that sense DNA damage cooperate to repair the DNA affected by UV light and environmental pollutants. By examining the interactions between these proteins, the study aims to understand the mechanisms that facilitate the repair of DNA mutations that can lead to serious health issues like cancer and aging. The research employs advanced techniques in single molecule and cell biology to analyze how these proteins bind to damaged DNA and work together to ensure effective repair. Patients may benefit from insights gained into DNA repair processes that could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to DNA damage, such as cancer and neurodegenerative diseases.
How similar studies have gone: Previous research has shown that understanding DNA repair mechanisms can lead to significant advancements in cancer treatment and prevention, indicating that this approach has potential for success.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Schaich, Matthew Allen — University of Pittsburgh at Pittsburgh
- Study coordinator: Schaich, Matthew Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.