How DNA repair and gene regulation work together in cancer
Official title: Interplay between DNA base excision repair and transcriptional regulation
Funded at Research Inst of Fox Chase Can Ctr · NIH-10940607 · Data updated 2026-11-12
This study is looking at how our bodies fix damaged DNA and how that affects the way certain cancer-related genes work, focusing on special DNA structures called G-quadruplexes, with the hope that this knowledge could help develop new treatments to improve DNA repair and gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $470,000 |
| NIH project number | 1R35GM155098-01 |
| Project ID | NIH-10940607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that involve mutations in DNA repair pathways.
✕Less likely to help
Patients with non-cancerous conditions or those whose DNA repair mechanisms are not implicated in their disease may not benefit from this research.
What this research studies
This research investigates the relationship between DNA damage repair and the regulation of gene expression, particularly in cancer-related genes. It focuses on specific DNA structures known as G-quadruplexes that are found near these genes and are prone to damage. By using advanced techniques like structural biology and single-molecule fluorescence, the research aims to uncover the mechanisms that link DNA repair processes to gene activation. This understanding could lead to new therapeutic strategies that enhance the body's ability to repair DNA and regulate gene expression effectively.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve DNA repair mechanisms and gene regulation in cancer patients.
How similar studies have gone: Other research has shown promising results in understanding DNA repair mechanisms and their implications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Whitaker, Amy Michelle — Research Inst of Fox Chase Can Ctr
- Study coordinator: Whitaker, Amy Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.