How DNA repair and gene activity are controlled by a specific protein modification.
Coordination of DNA repair and transcription by ubiquitin modification at DNA double strand breaks
This study is looking at how our cells fix serious DNA damage and how a special protein modification called ubiquitination helps with this process, which could lead to better treatments for diseases caused by DNA problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10817727 on NIH RePORTER |
What this research studies
This research investigates how DNA double-strand breaks, which are serious injuries to DNA, are repaired in cells. It focuses on the role of a protein modification called ubiquitination, which helps regulate the cellular response to these DNA damages. By studying how different types of ubiquitin modifications affect the recruitment of repair proteins and the suppression of gene activity at the damage sites, the research aims to uncover new mechanisms that could improve our understanding of DNA repair processes. This could lead to better strategies for treating diseases caused by DNA damage.
Who could benefit from this research
Good fit: Patients with conditions related to DNA damage or repair deficiencies, such as certain cancers or genetic disorders, would be ideal candidates.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not have any genetic predisposition to DNA repair issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases linked to DNA damage, such as cancer.
How similar studies have performed: Previous research has shown that understanding protein modifications like ubiquitination can significantly impact DNA repair mechanisms, indicating a promising avenue for further exploration.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Bin — University of Tx Md Anderson Can Ctr
- Study coordinator: Wang, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.