How DNA packaging units control gene activity
Biophysical Determinants of the Nucleosome as an Activity Center for Chromatin Regulators
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-11146594
This project explores how the physical features of nucleosomes, which package our DNA, help direct how genes are turned on and off.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11146594 on ClinicalTrials.gov |
What this research studies
Our bodies' DNA is carefully packaged into structures called nucleosomes, which were once thought to just block gene activity. However, we now understand that nucleosomes also act as important hubs, attracting and guiding proteins that control gene expression. This project aims to uncover how the specific shape and arrangement of these nucleosomes influence the activity of these gene-regulating proteins. Using advanced single-molecule techniques, we will observe these interactions in real-time to understand how the physical layout of our genetic material impacts its function. This foundational knowledge is key to understanding how our cells manage their genetic instructions.
Who could benefit from this research
Good fit: This basic science work does not involve direct patient participation, but its findings could be relevant to patients with conditions linked to gene regulation problems.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this fundamental laboratory research.
Why it matters
Potential benefit: This foundational understanding could eventually lead to new insights into how gene regulation goes wrong in diseases and potentially inspire new ways to correct these issues.
How similar studies have performed: Previous work by this team and others has already shown that nucleosomes play a more active role in gene regulation than previously thought, setting the stage for this deeper exploration.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, SHIXIN — ROCKEFELLER UNIVERSITY
- Study coordinator: LIU, SHIXIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.