How DNA packaging controls gene activity
Mechanisms of chromatin and transcriptional regulation
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11317196
This project looks at how proteins that package DNA control which genes are turned on or off, with relevance for cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11317196 on ClinicalTrials.gov |
What this research studies
The team will examine how histone-modifying enzymes and histone chaperones shape chromatin so genes are expressed correctly. They will study chemical tags on histones and how 'reader' proteins bind nucleosomes to trigger downstream events. Methods include biochemical and structural experiments and work in cell models that relate to cancer. Results aim to clarify basic rules of gene control that could later guide patient-focused tests or therapies.
Who could benefit from this research
Good fit: People with cancers tied to gene-regulation defects might be most likely to benefit from follow-up studies or future clinical work based on these findings.
Not a fit: Patients seeking immediate new treatments are unlikely to benefit directly because this is basic laboratory research rather than a clinical trial.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets for cancer diagnostics or future treatments.
How similar studies have performed: Previous laboratory studies have identified important histone modifiers and readers, but the specific mechanistic rules this project targets remain incompletely understood.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STRAHL, BRIAN D — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: STRAHL, BRIAN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers