How DNA damage repair proteins affect breast cancer growth and treatment resistance
Official title: Regulation of the tumor microenvironment by DNA damage repair proteins
Funded at San Diego State University · NIH-10888406 · Data updated 2026-11-12
This study is looking at how a protein called MLH1 affects estrogen receptor-positive breast cancer, aiming to find out how its loss might change the way cancer grows and responds to treatment, which could help develop better treatment options for patients with this type of cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $399,094 |
| NIH project number | 5R37CA270362-03 |
| Project ID | NIH-10888406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with estrogen receptor-positive breast cancer, especially those with known MLH1 loss.
✕Less likely to help
Patients with other types of breast cancer or those without MLH1 loss may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, MLH1, in estrogen receptor-positive (ER+) breast cancer, which is a common type of breast cancer. It aims to understand how the loss of MLH1 affects the secretion of certain molecules that can promote cancer growth and resistance to standard treatments. By using both laboratory experiments and animal models, the researchers will explore the mechanisms behind this process and how it may influence patient outcomes. The findings could lead to new strategies for treating patients with ER+ breast cancer who have MLH1 loss.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with ER+ breast cancer, particularly those with MLH1 loss.
How similar studies have gone: Previous research has shown that targeting molecular pathways related to DNA damage repair can be effective in treating certain cancers, suggesting potential for success in this area as well.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: Haricharan, Svasti — San Diego State University
- Study coordinator: Haricharan, Svasti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.