How DNA damage affects brain structure and stability in Alzheimer's disease
Impact of DNA double-strand breaks on 3D genome organization and genome stability in Alzheimer's disease
This study is looking at how breaks in DNA in brain cells might affect the way genes are organized in people with Alzheimer's disease, using mice and special human cells to find new ways to help slow down brain damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11159847 on NIH RePORTER |
What this research studies
This research investigates the role of DNA double-strand breaks (DSBs) in neurons and their impact on the 3D organization of the genome in Alzheimer's disease. By using mouse models and human induced pluripotent stem cell (iPSC) models, the study aims to understand how DSBs contribute to changes in genome structure and the response of glial cells. The goal is to identify molecular pathways that could be targeted for new therapies to prevent or slow down neurodegeneration associated with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those showing early signs of cognitive decline or with a family history of the disease.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic predisposition to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or slow the progression of Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding the role of DNA damage in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Dileep, Vishnu — Baylor College of Medicine
- Study coordinator: Dileep, Vishnu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.