How DNA Copies Itself in Cells
Choreography of Eukaryotic DNA Replication
This project looks at how cells make exact copies of their DNA, using baker's yeast to understand processes that can go wrong in human diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11088908 on NIH RePORTER |
What this research studies
Our cells constantly divide, and each time, they must perfectly copy their entire set of DNA. This project explores the precise steps cells take to duplicate their genetic material, a process called DNA replication. We are learning how cells decide where and when to start copying DNA, and how they manage this complex task. Understanding these fundamental steps is crucial because errors in DNA copying are linked to serious health problems, including cancer. By studying baker's yeast, which shares many basic cell processes with humans, we can uncover vital insights into how DNA replication works correctly and what happens when it doesn't.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals with cancers linked to DNA replication issues.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how cancer develops and potentially new ways to prevent or treat it by targeting DNA replication errors.
How similar studies have performed: This project builds upon existing knowledge of cell biology and DNA replication, using a well-established model organism (baker's yeast) for fundamental discoveries.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Brewer, Bonita J — University of Washington
- Study coordinator: Brewer, Bonita J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.